Comparative Study on the Anti-proliferation and Apoptosis-inducing Effects of Active Components from Four Glycyrrhiza Species on Human Breast Cancer BCAP-37 Cell
Abstract:ObjectiveTo select the optimal glycyrrhiza species for medicinal utilization by comparing the anti-proliferation and apoptosis-inducing effects of active components from four wild glycyrrhiza species in Xinjiang on human breast cancer BCAP37 cell. MethodsThe anti-proliferation effects of different samples on BCAP37 cell were measured by MTT assay. The cell apoptotic rate was detected by Hoechst 33258 stain.ResultsActive components of four Glycyrrhiza species inhibited the proliferation of BCAP37 cells and induced apoptosis significantly. What's more, there were significant interspecific and spatial variations in the anti-proliferation and apoptosis-inducing effects. ConclusionThe optimal Glycyrrhiza species for anticancer utilization is Glycyrrhiza alalensis L.
Key words:Glycyrrhiza; Active Component; Human breast cancer BCAP37 Cell
[5]Liu Y H.Fu K Z.Content of main chemical components of Glycyrrhiza uralensis Fisch.in different soil environment[J].Chin J Veter Drug (中国兽药杂志),1996,30(4):26.
[6]Liu P Y.Hu H F.Yan Z.et a1.Colorimetric estimation of glycyrrhizin content in Glycyrrhiza inflata produced in four provinces[J].J Hebei Univ (河北大学学报),1998.18(4):369.
[7]Gu H Y.Gong L D.Yu J H.Measurement and comparison of glycyrrhizic acid contents in root of licorice (Glycyrrhiza uralensis Fisch.)from different cultivation areas [J].J forest Res(林业研究),2002,13(2):141.