Study on the Changes of Cellular Immune Function of Aging Rats and the Anti-aging Effects of Traditional Chinese Medicine Tiannianyin
Abstract:ObjectiveTo study on the changes of cellular immune function of aging rats and the anti-aging effects of traditional Chinese medicine Tiannianyin.Methods40 SD rats were divided into 4 groups at random: normal group, aging model group, Tiannianyin group and negative control group, each group had 10 rats. The sub-acute aging model rats were made by injecting D-gal into abdominal cavity continually. ELISA was used to detect the IL-2 and IL-6 content in serum, the macrophagic phagocytosis and thymus index were also observed. ResultsCompared with normal rats, the IL-2 content in serum, the thymus index and the macrophagic phagocytosis of aging rats decreased obviously (P<0.05,P<0.01); the IL-6 content in serum increased obviously (P<0.01). Tiannianyin not only significantly increased the IL-2 content, the macrophagic phagocytosis and the thymus index of aging rats (Tiannianyin group compared with aging group: P<0.01, P<0.05); but also significantly decreased the IL-6 content of aging rats (Tiannianyin group compared with aging group: P<0.01).ConclusionsTianninyin can strengthen the cellular immune function of aging rats, so it has fairly anti-aging effects.