Abstract:ObjectiveTo study osteoporosis of cyclophosphamide and investigate the preventive effects of Shuangdan oral liquid on rats.MethodsCyclophosphamide at the dose of 4.5 mg·kg-1·d-1 was given to the rats orally for 15 days while Shuangdan oral liquid and calcium and vitamin D3 were given to cyclophosphamide-treated rats orally. At the experiment, bone biomechanics analysis of the right femur were performed in fresh sections. Then the hydroxyproline, Ca, P, Mg of bone were tested.ResultsBiomechanics property and bone mineral on femur of rats decreased significantly.ConclusionShuangdan oral liquid can prevent osteopathologic change from cyclophosphamide-induced on rats.
Key words:Shuangdan oral liquid; Cyclophosphamide; Calcium and vitamin D3; Rats; Bone mineral; Bone biomechanics
【参考文献】
Abstract:ObjectiveTo study osteoporosis of cyclophosphamide and investigate the preventive effects of Shuangdan oral liquid on rats.MethodsCyclophosphamide at the dose of 4.5 mg·kg-1·d-1 was given to the rats orally for 15 days while Shuangdan oral liquid and calcium and vitamin D3 were given to cyclophosphamide-treated rats orally. At the experiment, bone biomechanics analysis of the right femur were performed in fresh sections. Then the hydroxyproline, Ca, P, Mg of bone were tested.ResultsBiomechanics property and bone mineral on femur of rats decreased significantly.ConclusionShuangdan oral liquid can prevent osteopathologic change from cyclophosphamide-induced on rats.
Key words:Shuangdan oral liquid; Cyclophosphamide; Calcium and vitamin D3; Rats; Bone mineral; Bone biomechanics