Abstract:ObjectiveTo observe effects of Ling Qijuan Gan Liquor(LQL)on extracellar matrix in rats with hepatic fibrosis.MethodsThe model of hepatic fibrosis was induced by carbon tetrachloride . The changes of serum fibrosis index hyaluronis acid(HA),laminine(LN),prosollagenⅢ(PCⅢ),collagenⅣ(CIV)and hydxy-proline(Hyp)in liver homogenates were measured.Liver tissues were taken to do pathological examination.ResultsCompared with model group,LQL could notably reduce HA,LN,PCⅢ,CIV and Hyp when livers were chronic damaged,the differences were striking(P<0.05).Pathol examination found that LQL could lighten denaturalization of liver fat and reduce hyperblasia of fibrous tissue and accelerate rebirth of liver cell.ConclusionLQL can modulate the metabolism of ECM and reduce sediment of ECM and then alleviate hepatic fibrosis.