Abstract:ObjectiveTo evaluate the safety of Yinxingdamo (Freeze-dried Power). Injected by testing the muscle stimulation, vessel stimulation, active systematic anaphylaxis, passive cutaneous anaphylaxis and haemolytic test.MethodsIn the muscle stimulation test, two rabbits were observed at 48 h after injection Yinxingdamo (Freeze-dried Power); In the vessel stimulation, four rabbits were observed on the 5 d after injection Yinxingdamo (Freeze-dried Power), and the reaction after stopped treatment 14 d. Active systematic anaphylaxis was investigated by male guinea pigs, reaction was observed the 14d and 21d after the first treatment. The rat passive cutaneous anaphylaxis reaction was assayed by Evans blue. In the haemolytic test, hemolysis and coagulation were mainly observed. ResultsYinxingdamo (Freeze-dried power) injection had no stimulation to muscle and ear vein of rabbit, the guinea pigs and rats had no allergic reaction as contrast and without hemolytic reaction.ConclusionYinxingdamo (Freeze-dried Power) injection is safe and reliable based on the animal experiment.